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pentobarbital will decrease the extent or effect of methylprednisolone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lessen the extent or effect of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Watch Carefully (one)pentobarbital will lessen the extent or impact of levamlodipin